“  ….in many autistic children, bacterial and fungal
overgrowths are etiologically significant in the cascade
of events that result in autism or one of the other autism
spectrum disorders.”
By Jaquelyn McCandless in Children with Starving Brains.

             “A sensible and harmless form of warfare on the
aberrant population of intestinal microbes is to manipulate
their energy (food) supply through diet… By depriving
intestinal microbes of their energy source, their numbers
gradually decrease along with the products they
produce.”
By Elaine Gottschall in Breaking the Vicious Cycle.

                 “Janie played with a doll for the first time ever
today; I almost fainted. She initiated a hug and kiss for
the first time ever in her 14 years of life.”
From Mom of Janie with Down’s syndrome, autism and gastrointestinal issues after a short time on the Specific
Carbohydrate Diet.

         The Specific Carbohydrate Diet™ has entered the world
of autism through “the back door”- the intestinal tract. And
what may have first appeared to be “the back door,” via the
digestive system, is rapidly becoming one of the most
scientifically researched areas in determining what may be
one of the underlying causes of many autism spectrum disorders.  Because the Specific Carbohydrate Diet™’s goal is to heal the intestinal tract and to rid it of bacterial and fungal overgrowth, it is proving to be a very successful dietary intervention in treating many autistic children and leading them back to a life of normalcy.

            This chapter will review some of the research dealing
with the Gut-Brain Axis in child developmental disorders. It
will point out how dietary intervention with the Specific
Carbohydrate Diet addresses and often overcomes conditions
thought to be at the root of autism spectrum disorders as well
as some cases of epilepsy and attention deficit disorder
(ADD).
             The previous chapter, The Brain Connection, highlights
the research of many years in which it had been shown
that various neurological problems originate in the digestive
system. And when the number of autistic children soared
within the last two decades, attention has again been directed
to the gastrointestinal tract.
            Parents of autistic children have always known that,
among their children’s symptoms, there exists symptoms of
chronic constipation, periods of diarrhea, and abdominal pain.
But until recently, the parents’ reports were treated as of no
consequence. Now, fortunately, attention is being focused on
these physical symptoms as well as on behavior, and many
gastroenterologists are in agreement that “these children are
ill and are in distress and pain, and not just neurologically
dysfunctional.” 1
           Some physicians, recognizing that diet was playing a
part in causing the intestinal symptoms focused their attention
on treating these gastrointestinal symptoms as allergies and/or sensitivities. When testing these patients, they found evidence of sensitivities to various food components, mainly the gluten of grains and various components of dairy products. The behavior of many autistic children, although not all, showed improvement with the removal of these foods from their diet but, unfortunately, although behavior often improved, intestinal function did not. It was not unusual for the author to receive letters from parents as follows:

           “My son is almost six years old and has autism. He was gluten/casein free for two years and while, during the first six months I thought I saw improvement in his  exhibiting less stimmy (repeating the same action  over  and over again), his stimming returned. Even while on this diet, he still had constant stomach problems - being  hospitalized four times for throwing up and dehydration.  One time he suffered with a bowel obstruction; the other  times they weren’t sure what brought on his violent vomiting attacks. No doctor even bothered to do a colonoscope.  I have mentioned to our doctor for years that he seems to be addicted to potato chips, french fries, ketchup, and waffles. When I learned of the Specific Carbohydrate Diet™, it addressed this carbohydrate addiction and I intend startingthis diet promptly.”

And another letter from Patricia :
             “… Meanwhile, my younger child’s health was failing. He was on a strict gluten-free diet because of celiac disease.But it wasn’t helping. He was ghost white and rail
thin, with little energy and with chronic diarrhea and black
circles under his eyes. Deep down, I worried he was dying. The team of pediatric specialists we were seeing had no clue how to make my little boy healthy, nor did my daughter’s“ alternative” DAN (Defeat Autism Now) physician. Fortunately, for us, this was August. And every doctortreating my son was on vacation.
             In desperation, I picked up a book called Breaking the Vicious Cycle: Intestinal Health through Diet by Elaine
Gottschall. A stranger had mailed this book to me two
months earlier after meeting my Mother and hearing about
my son’s deteriorating health.
            The book explained why my son wasn’t thriving on
the regular celiac diet. His intestines were so damaged he
couldn’t digest any grains, or complex carbohydrates. The
next day, he started the so-called Specific Carbohydrate
Diet™(SCD™) described in this book. His stools became normal, and he started growing and gaining weight. He’s
now a strong, healthy seven-year old.

         What about my daughter? She had no obvious digestion troubles, but she did have “autism” and a recently discovered yeast overgrowth. One British researcher found a link between the MMR shot, intestinal problems, and autism. Wouldn’t a diet that promised to heal her intestines and help with yeast overgrowth be her best shot at normal life?
          We put Maria on a dairy-free version of the SCD™. She had a terrible yeast die-off that lasted a week even though she was taking Nystatin, a popular antifungal drug. But once she recovered from the die-off, about a week later, we were confident she’d someday grow into an Independent adult, thanks to this remarkable diet. Her remaining speech peculiarities, such as mixing up the order of words in a sentence, disappeared. Her eye contact became normal. By the time she was 4-1/2, one year after her diagnosis, no one would guess she was ever “autistic.”

              These parents’ reports are echoed throughout the
autistic community: although various dietary proteins appear
to aggravate behavioral symptoms, their removal is not
addressing the gastrointestinal problems. In addition it becomes increasingly apparent that as a few dietary proteins are removed, more and more must be taken out of the diet to hopefully achieve and sustain progress until these children have little to eat in the way of nutritious food. Parents continuously complain of their children’s addiction to carbohydrates.
               Dr. J. O. Hunter in 1991 described this dilemma of
treating patients with gastrointestinal symptoms as food
allergies or sensitivities. He stated that patients who exhibit
sensitivities do not follow classical Type I allergic reaction. If
these intolerances are not allergies, then they may be a disorder
of bacterial fermentation in the colon and the disorders
might be more appropriately named “enterometabolic (intestinal)
disorders.” 2
              The Specific Carbohydrate Diet™ approaches these gastrointestinal challenges in autism as it has been successfully
doing for inflammatory bowel disease - as a disorder of bacterial fermentation and the ensuing problems which occur because of bacterial fermentation. These problems resulting  from bacterial fermentation are: (1) production of excess amounts of short chain volatile fatty acids (organic acids):  (2) lowering of the pH of the blood as these acids are  absorbed: (3) overgrowth of bacteria as the undigested carbohydrates provide food for bacterial proliferation: (4) mutation of some bacteria such as E. coli because of the change in pH in their colonic environment; and (5) excess toxin production caused by the overgrowth of some pathological bacteria.
               Bacterial fermentation occurs when undigested carbohydrates escape digestion and absorption and end up in the lower parts of the small intestine and colon. Unlike diets that
eliminate only certain proteins, based on tests showing sensitivities to proteins, and that allow unlimited intake of starches and sugars, the Specific Carbohydrate Diet™ (SCD™) is
designed to nourish the child optimally and to minimize bacterial
fermentation.
               Coleman and Blass in 1985 in The Journal of
Developmental Disorders reported the first evidence that
autism might be linked to carbohydrate metabolism (digestion).
3 These researchers reported that the syndrome of D-lactic
acidosis was found to be present in autistic children.
Their work was based on reports of the 1970’s and 1980’s
showing that undigested carbohydrates were being changed
by bacterial action in the intestine to a substance, D-lactic
acid. High amounts of D-lactic acid in the bloodstream have
been found to cause bizarre behavioral symptoms. This book
discusses earlier research relating to D-lactic acidosis in
Chapter 7, The Brain Connection.  4, 5, 6, 7, 8, 9, 10
                 There are two approaches to treating this abnormal
production of D-lactic acid: (1) use of antibiotics to kill the
bacteria producing the substance, a method often used med-
ically, and (2) decreasing the amount of fermentable carbohydrates upon which bacteria feed in order to produce
D-lactic acid. Since antibiotic therapy often is accompanied by other side effects, it seems reasonable to suggest dietary changes to accomplish the same thing or as a support for medical intervention with antibiotics.
               The year 2000 yielded landmark research in linking
autism to the gastrointestinal tract. It was reported that among 385 children on the autism spectrum, significant gastrointestinal
symptoms occurred in 46% compared with only 10% of almost 100 children without autism confirming what parents already knew. 11
              A flurry of remarkable scientific papers appeared, first,
in the British medical journal, Lancet 12 and then in The
American Journal of Gastroenterology (Wakefield) 13, demonstrating conclusively that serious intestinal pathology was
found more than half of autistic patients. These intestinal
problems ranged from moderate to severe including esophagitis, gastritis and enterocolitis along with the presence of lymphoid nodular hyperplasia. Some of these intestinal pathologies resembled Crohn’s disease as well as ulcerative colitis. As would be expected, from previous research done on intestinal problems (see pages 22-24), it was also found by
Horvath et al 14 that there was low carbohydrate digestive
enzyme activity (see diagrams of injured microvilli in the
chapter on Carbohydrate Digestion) although the pancreatic
function was normal.
               Horvath’s report concluded by saying unrecognized
gastrointestinal disorders, especially reflux esophagitis and
disaccharide malabsorption, may contribute to the behavioral
problems of the non-verbal autistic patients.
Additional reports from findings at Harvard Massachusetts General Hospital conclusively showed that carbohydrate digestion is being hampered at the locus of the
intestinal absorptive cell.15
          Initial autism research findings at Harvard Massachusetts General testing 400 autistic children found that (1) lactase deficiency was found in 55% of ASD children tested; (2) combined deficiency of disaccharidase enzymes was found in 15%; and (3) enzyme assays correlate well with hydrogen breath tests. (The hydrogen breath test measures the amount of hydrogen gas given off when intestinal microbes ferment unabsorbed carbohydrates.)
          This current work, on decrease in digestibility of
dietary disaccharides leading to malabsorption, forms the
basis for therapy of the Specific Carbohydrate Diet™. Its goal is
to keep disaccharide ingestion to a minimum by avoiding lactose, sucrose, maltose and isomaltose (remnants of starch
digestion) and to provide a nutritious, healing diet without
these double sugars and to deprive the microbial world of the
intestine from a surplus of fermentable carbohydrates.
            It is well known that compounds arising in the intestinal
tract can enter the bloodstream and cross the blood brain
barrier.16 Gastroenterologists have been aware of this in
treating the neurological effects of liver disease, hepatic
encephalopathy. Reports have been published on how these
toxins from the intestinal tract affect neurotransmitter substances
in the brain.17 Other research by E.R.Bolte18 in an effort to correlate autism behavioral symptoms to the intestinal tract, investigated how the toxin of one bacterium, Clostridium tetani, could find its way from the intestinal tract to the central nervous system via the vagus nerve.
              But there is still disagreement among researchers as to
what constitutes the toxins from the gastrointestinal tract and
what their origins are. Again, are they derived from proteins
or are they products of intestinal bacterial action? This question
was addressed in an outstanding research paper published
in Neuropsychobiology in 2002 and authored by Dr. Harumi Jyonouchi et al.19 Dr. Jyonouchi’s group were the first to explain how bacterial toxins from the intestine can result in
sensitivities to certain dietary proteins, and casts light on the
conundrum of which comes first: allergies/sensitivities which
might lead to intestinal inflammation, or bacterial and yeast
overgrowth (infections) which can lead to sensitivities to certain
dietary proteins. The question can be viewed as “can the
body’s innate immune system, by reacting to the toxins of
certain bacterial cell walls, cause the sensitivities to proteins
such as casein and gluten?” The authors suggest that the root
cause of the food protein sensitivity may be an underlying
sensitivity to endotoxin, which arises from the surfaces of
gram-negative bacteria in the gut flora: the lipopolysaccharide
component of the cell wall of certain bacteria present in
the intestine.20
             This response to an endotoxin of intestinal bacterial
cells is considered an innate immune response, an ancient
form of defense and coded in the genes as an inherited trait.
This innate immune response to the bacterial toxin could
stimulate the production of antibodies and cytokines, initiators
of an inflammatory response, part of an adaptive immune
response.21 Dr. Jyonouchi’s research is an attempt to answer
the question of why there is gastrointestinal pathology in children
exhibiting autism spectrum disorders and invites the
research community to explore dietary intervention in order to
ameliorate the behavioral symptoms of autism.
               It is the hope of the author that this book will be of
help to the research community in understanding how the
molecular components of commonly eaten foods affect this
problem and how changing the child’s diet can, indeed, break
the vicious cycle.

**************************************

Important note to parents of autistic children:
             When implementing The Specific Carbohydrate Diet™, it
is important to remember that during the first week to ten
days, profound changes are occurring in the digestive tract:
the hundreds of different families of microorganisms are
changing their metabolic functions due to the lack of nutrients
to which they have been accustomed and of which they are
now being deprived Some children may do well even during
the first week. But others will go through a period of adjustment
which some refer to as “detoxification.” It will be helpful
during this period to find support from the many other
parents who have been through this change. Going to the following websites can give you this support.
                It is especially important that you read the information
on these websites relating to the introduction of dairy products.
A decision can then be made if the Specific Carbohydrate Diet™ should be implemented with or without dairy.

http://www.pecanbread.com/
http://www.breakingtheviciouscycle.info